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Long‑Acting Injectable (LAI) Therapy for People with HIV – Executive Summary

This executive summary highlights lessons learned from the longer-standing experiences of delivering LAIs for other chronic conditions in the fields of mental health and addiction offer insights into the use of newly available LAIs for HIV prevention and treatment. A socio-ecological framework was used to discuss issues surrounding the implementation of LAIs for all three types of conditions and explore ways to maximize potential benefits for HIV.

Type Population Topics Reports People with HIV (HIV+) Long-Acting Injectable

Technology Based PrEP Delivery for Black and Latina Cisgender Women in Los Angeles County – Report

This report highlights the urgent need to consider innovative strategies to connect BLCW with PrEP services. As part of a NIMH EHE supplement project, the UCLA CHIPTS received funding to develop and pilot an implementation strategy to increase PrEP awareness and optimize PrEP uptake among BLCW through the use of the PlushCare telemedicine application.

Type Black/ African American (BAA) Population Topics Women Latinx/ Hispanic Reports Research Tools and Materials PEP/PrEP Reports/Presentations Linkage to/ Retention in Care Technology Women Pre-Exposure Prophylaxis Surveillance/ Investigation Technology

Equity and Access: A Roadmap to Improving Vaccination Equity in South Los Angeles

This project was led by researchers from the University of California, Los Angeles and Charles R. Drew University of Medicine and Science in collaboration with the California Community Foundation to advise and provide insights on how to reach communities of color and those hardly reached to educate, build trust, and disseminate vaccines in South Los Angeles given historical experiences with medical mistrust. The efforts center around three goals, which are to:  (1) Facilitate community, public, private, and governmental partnerships to reduce, COVID-19 vaccine inequity. (2) Educate communities of color in South LA about the COVID-19 vaccines through virtual town halls, and (3) Navigate communities of color in South LA on how to access available COVID-19 vaccines.

Access to Care Type Black/ African American (BAA) Population Topics Latinx/ Hispanic Reports

Recommended Solutions for Engaging Patients and Increasing Vaccination Rates – Summary Report

Summary of recommendations by Alma Guerrero, Department of Pediatrics, UCLA for the COVID-19 Roundtable Providers Summit on Tuesday, August 31, 2021. The recommendations focused on mobilizing service providers, improving patient-provider interaction, and the increase of vaccination rates.

Type Access to Care Population Topics Reports Manuals Research Tools and Materials Service Providers

COVID-19 Community Resource Guide

The resource guide is organized as a list containing the information of various community partners that were invited speakers at the COVID-19 Community Leadership Summit. The information provided is related to COVID-19 vaccination efforts and incorporates a point of contact for any additional information if needed. The resource guide is meant to be shared to support on-going efforts to increase COVID-19 vaccines.

Type Topics Reports Research Tools and Materials Manuals Strategizing/ Engagement Methods

HIV & Medical Mistrust: A Summary (2021)

Report Summary by Laura M. Bogart that describes medical mistrust as a key contributor to racial/ethnic health and healthcare disparities in the U.S, the serious health consequences for people living with and at risk for HIV, and how medical mistrust also can affect views about HIV.

Policy Brief Type Policy Materials Topics Discrimination Reports Medical Mistrust

Taking Strategic Action to Address Substance Use in California – EHE Regional Meeting Summary Report

Addressing substance use in California was identified as a key priority for the Ending the HIV Epidemic (EHE) Regional Response across California’s EHE Phase 1 counties. On October 20 and October 27, 2020, CHIPTS and the CHPRC hosted a two-part EHE Regional Meeting. This event brought together over 100 stakeholders from California’s EHE Phase 1 counties, as well as other partners working at the intersection of HIV and substance use across the state, to discuss how to move evidence-based strategies forward to address substance use. The report is a summary of the event and key findings that will address substance use in CA EHE Phase 1 counties.

Type Topics Reports HIV Infection/ Transmission Substance Use

Is Injectable PrEP safe and effective? New research findings from HPTN 083 – Fact Sheet

HIV Prevention Trials Network (HPTN) 083 is a randomized, active-controlled, double-blind clinical trial that began in December 2016. The study has compared the safety and efficacy of two drugs for use as PrEP among a population at increased risk of HIV infection.

Type CHIPTS Topics Long-Acting Injectables Reports PEP/PrEP Long-Acting Injectable Pre-Exposure Prophylaxis

Preparing for long-acting injectable antiretroviral therapy for HIV in Los Angeles – Preliminary Findings Report

CHIPTS conducted a formative study to provide the groundwork to support successful implementation of LAI ART in Los Angeles County. The aims of this study were to strengthen and develop partnerships and build capacity in partners to support research on implementation of LAI ART as part of a strategy to optimize viral suppression in Los Angeles County; To assess the policy, systems, financial, operational and clinical level barriers to and facilitators of the rollout and scale-up of LAI ART in Los Angeles County; and to assess the end-user (consumer) perceived barriers to and facilitators of LAI ART use in Los Angeles County. This report summarizes the preliminary study findings and recommendations to inform efforts to prepare for implementation of LAI ART in Los Angeles County.

Type CHIPTS Antiretroviral Therapy Topics Implementation Research Long-Acting Injectables Reports Reports/Presentations Long-Acting Injectable Viral Suppression

Technology-Based PrEP Delivery and Retention Services for Black and Latino MSM, Black and Latina Transgender Women, Black and Latina Cisgender Women, and Persons Who Inject Drugs in Los Angeles County – Summary Report

This report summarizes the preliminary findings and next steps emerging from the “Technology-Based PrEP Delivery and Retention Services for Black and Latino MSM, Black and Latina Transgender Women, Black and Latina Cisgender Women, and Persons Who Inject Drugs in Los Angeles County” community consultation. The report includes a description of the study procedures, preliminary results, and recommendations for future implementation.

Type Black/ African American (BAA) Population Topics Latinx/ Hispanic Implementation Research Men who have sex with men (MSM) Reports PEP/PrEP Reports/Presentations Linkage to/ Retention in Care Transgender Persons Women Pre-Exposure Prophylaxis Substance Use Technology

A Regional Response to End the HIV Epidemic in California – Key Findings and Recommendations Report

CHIPTS received a supplement award to engage a regional effort for coordinated EHE response in California. This award supported CHIPTS to bring together stakeholders from across the California priority counties; assess existing resources, key needs, and collaborative opportunities; and provide recommendations to help facilitate a regional EHE response. This document synthesizes the information CHIPTS gathered and offers actionable recommendations to support a coordinated regional response to the HIV epidemic in California.

Type Community CHIPTS Topics Implementation Research Reports Reports/Presentations Strategizing/ Engagement Methods

LA HIV Commission Panel for NBHAAD – Reflection

Dr. Nina Harawa reflected on today’s panel in honor of NBHAAD she raised a range of issues, concerns, and solutions. Among other points, the stellar group of committed provider/advocates highlighted the changing healthcare landscape and workforce training needs. The latter issue particularly drew my attention. It is on days like these that I realize I have been in the HIV fight, in this corner of the epidemic, for a long time. Others have been in it even longer and will soon retire.

Type Black/ African American (BAA) Population Topics Reports Reports/Presentations Linkage to/ Retention in Care Stigma

Nina Harawa Commentary on HIV Commission Panel Discussion to Commemorate National Black HIV/AIDS Awareness Day (NBHAAD)

Dr. Nina Harawa attended the HIV Commission Panel Discussion to Commemorate National Black HIV/AIDS Awareness Day. The panel was organized by members of the Black Caucus on the Los Angeles Commission on HIV. A crucial part of the panelists’ call was to increase the numbers of Black providers and researchers in the area of HIV. Dr. Harawa describes the vital role that Black/African American providers play in serving the needs of Black patients, including the ability to forge trusting partnerships with patients.

Type Black/ African American (BAA) Population Topics Implementation Research Discrimination Reports Reports/Presentations Mental Health Stigma Substance Use

CHIPTS CAB Guidelines

Report of the guidelines of the CHIPTS Community Advisory Board (CAB), CAB members are responsible for advising CHIPTS research, disseminating research information and providing community perspective on various activities and functions of CHIPTS. The report further describes ways of nominating CAB members and criteria for membership.

Type Reports Manuals Research Tools and Materials

U.S. Preventive Services Task Force Issues Final Recommendation Statements on HIV Screening and HIV Prevention

The U.S. Preventive Services Task Force (Task Force) published final recommendation statements on HIV screening and HIV prevention. Based on its review of the evidence, the Task Force recommends that clinicians screen for HIV in everyone ages 15 to 65 years and all pregnant people. Younger adolescents and older adults at increased risk for HIV should also be screened. The Task Force also recommends that clinicians offer pre-exposure prophylaxis (PrEP)—a pill that helps prevent HIV—to people at high risk of HIV.

Type Condoms Topics Reports Reports/Presentations Pre-Exposure Prophylaxis Prevention Testing

Early Child Development – HIV Exposed Children Learning Session Final Report

Summary report of the Learning Session: HIV Exposed Children and Early Child Development on March 7, 2019. The report includes descriptions of the opening remarks by Thomas Coates, UCLA DGSOM, presentations by featured guests, and closing remarks. The presentations include background context, summary, and discussion points.

Type Global HIV Living with HIV Reports Reports/Presentations Conference Proceedings Children Parenting

Slowing the Emerging Opioid Epidemic in Southern California: Responding to Increases in Opioid, Prescription, and Injection Drug Use Meeting Report

Slowing the Emerging Opioid Epidemic in California Friday, November 16, 2018, meeting summary report. The purpose of the meeting is to convene a cross-disciplinary group of experts at UCLA to consider current science and policy considerations related to the US opioid crisis, discuss California opioid surveillance data and research opportunities related to preventing an outbreak in the region, and consider the implications for vulnerable populations with a particular focus on those groups affected by HIV (e.g., people who inject drugs [PWID], substance-using minority men who have sex with men [MSM] of color)

Type Agenda/Flyers Topics Living with HIV Reports Reports/Presentations Substance Use Substance Use Surveillance/ Investigation

Los Angeles County Sentinel Community Site (SCS) Drug Use Patterns and Trends (2018) – Report

This report highlights key findings, drug use patterns and trends across methamphetamine, fentanyl, heroin, prescription drugs/opioids, and other synthetic drugs using the National Drug Early Warning System.

Type Topics Reports Los Angeles HIV Data Reports/Presentations Substance Use Surveillance/ Investigation

Stimulant Use: Harm Reduction, Treatment, and Future Directions Conference – Report

In September 2017, the Drug Policy Alliance organized a conference in Los Angeles in partnership with over a dozen organizations titled “Stimulant Use: Harm Reduction, Treatment, and Future Directions.” The conference aimed to bring much-needed attention to a large class of drugs that has received inconsistent attention from the media, harm reduction and treatment communities, researchers, and policymakers alike. Los Angeles was chosen for this conference due to its sustained and high prevalence of use of stimulants both historically and currently.

Type Topics Reports Reports/Presentations Substance Use

2016 HRSA Biennial Report

In 2016, HAB reviewed and updated its six strategic priorities. To highlight the innovative models of care that RWHAP recipients implement in communities across the country, HAB publishes a report every two years. These reports provide an update of RWHAP efforts to improve health outcomes for PLWH, showcase data on client demographics and services received, and document the successes and challenges of recipients. This report highlights the activities of six RWHAP recipients and illustrates how they are harnessing data to reduce disparities in HIV care and improve health outcomes for PLWH.

Access to Care Type Population Topics Reports Reports/Presentations People with HIV (HIV+) Strategizing/ Engagement Methods Testing

LA County HIV/AIDS Strategy for 2020 and Beyond

This is a strategy that calls on the vast, complex, and formidable private health care delivery system (e.g. health plans, hospitals, federally qualified health centers and community-based organizations) as equally as the publicly-operated hospitals, public health clinics, and comprehensive health centers that serve the residents of Los Angeles County. This is a strategy that responds to an appeal from the Los Angeles County Commission on HIV (Commission) and hundreds of active and passionate community providers and stakeholders for bold action and a clear vision for ending an epidemic that nears the start of its fifth decade. This is a strategy that introduces an unprecedented level of accountability, and a commitment to the public reporting and monitoring of key performance metrics.

Type Population Topics Reports Los Angeles HIV Data Reports/Presentations People with HIV (HIV+) Mental Health Strategizing/ Engagement Methods Substance Use Viral Suppression

The Williams Institute Report on Conversion Therapy and LGBT Youth

Executive Summary by the The Williams Institute that describes conversion therapy as a treatment grounded in the belief that being LGBT is abnormal. It is intended to change the sexual orientation, gender identity, or gender expression of LGBT people. Conversion therapy is practiced by some licensed professionals in the context of providing health care and by some clergy or other spiritual advisors in the context of religious practice. Efforts to change someone’s sexual orientation or gender identity are associated with poor mental health, including suicidality. To date, nine states, the District of Columbia, and 32 localities have banned health care professionals from using conversion therapy on youth.

Type Population Topics Reports Reports/Presentations Mental Health Youth and Adolescents

Covered California FAQ: For People Living with HIV and Hep C and People Considering PrEP

This FAQ is meant to answer a set of common questions and answers intended to help you enroll in and better understand your coverage through Covered California. This guide is designed specifically to help people living with HIV and hepatitis C and people considering preexposure prophylaxis (PrEP).

Type Population Cost of Care Topics Living with HIV Reports Manuals STD People with HIV (HIV+) Pre-Exposure Prophylaxis

LAC DPH Health Alert: Mumps Outbreak in Adults in Los Angeles County – Report

This report discusses Mumps as a highly infectious disease that has spread through congregate living/social settings causing sporadic outbreaks as has been demonstrated in recent outbreaks in the United States. The report lists actions requested of providers to address the Mumps outbreak.

Type Population Topics Reports Surveillance/ Investigation

HIV Prevention Study Does Not Confirm Tenofovir Gel Effectiveness – Press Release

The press release highlights a major study has shown that a vaginal gel containing the antiretroviral drug, tenofovir, was not effective in preventing HIV among a large, diverse population of young South African women. Findings of the study, known as FACTS 001, were reported at the annual Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, United States earlier today (Tuesday 24 February).

Type Antiretroviral Therapy Population Topics Reports HIV Infection/ Transmission Publications Non-US Populations Women Tenofovir

Next Generation Oral Preexposure Prophylaxis – Report

Clinical trials of oral preexposure prophylaxis (PrEP) have focused on regimens of tenofovir (TDF) with or without emtricitabine (FTC). However, TDF may be associated with toxicities (renal, bone), and FTC may select for drug resistance. Both are also first-line drugs for HIV treatment. In this review, we discuss agents that might serve as alternatives to TDF/FTC for HIV PrEP.

Type Topics Reports PEP/PrEP Publications Pre-Exposure Prophylaxis

Mobile Phone Adherence and Prevention Support for People Living with HIV in India – Research Plan

HIV is a significant risk in India, with increasing numbers of Persons Living with HIV (PLH) who are seeking and receiving treatment. While increasing numbers of PLH are receiving access to treatment, creating the possibility of reduced viral load and HIV transmission, non-adherence is high. Low ART and medical adherence (and high viral loads) are associated with a constellation of risks that undermine adherence and prevention, including sexual and drug use transmission behaviors, depression, social isolation and low social support.

Type Global HIV Antiretroviral Therapy Population Topics Living with HIV Reports HIV Infection/ Transmission Non-US Populations People with HIV (HIV+) Technology Technology Viral Suppression

Story of Champions League Player Yolani Benge – Report

Type Global HIV Population Topics Reports Substance Use Youth and Adolescents Substance Use

Will and Should Women in the U.S. Use PrEP? Findings from a Focus Group Study of At-risk HIV-negative Women in Oakland, Memphis, San Diego, and Washington, DC – Report

Most US Women at risk of HIV infection are unaware of PrEP, this focus group report captures the opinions about PrEP as highly nuanced. With a demonstrated high level of efficacy, with correct and complete information from trusted sources, and wit an assured way of paying for Prep, it was viewed as an option that should be available to all kinds of women who are having sex whether or not they perceive themselves at risk of HIV infection. Cost, access, and side effects are the most critical concerns U.S. women express about Prep.

Access to Care Type Population Topics Women Reports PEP/PrEP Publications Women Pre-Exposure Prophylaxis

Substance Use, Mental Health and HIV: Integrating Treatment as Prevention (2011) – Report

This report is a summary of the Substance Use, Mental Health and HIV: Integrating Treatment as Prevention conference that took place in Atlanta, Georgia in 2011. The report includes a summary of the opening plenary that provided an overview of the HIV epidemic in the US and afternoon plenary that closed the conference with an overview of the fundamental changes to discussion, dialogue, and possibilities in the era of treatment as prevention. In between were three sessions: session one focused on treatment as prevention for substance users and MSM. Session two focused on treatment as prevention for mental health providers. Lastly session three focused on paying for mental health and substance abuse drugs for persons living with HIV.

Type Topics Reports Reports/Presentations Mental Health Substance Use Conference Proceedings

HIV Testing: Global Challenges, Global Strategies, Global Impact (2010) – Report

This conference was held on July 17th, 2010, in Vienna, Austria, one day prior to commencement of the XVIII International AIDS Conference. The one-day conference was sponsored by the Center for HIV Identification, Prevention and Treatment Services (CHIPTS) in collaboration with the National Institute of Mental Health and the Ford Foundation. As the fourth of five annual meetings looking at the social and behavioral implications of emerging biomedical interventions for HIV prevention, the conference brought together leaders in program implementation and biomedical, behavioral, and economic research to identify and discuss opportunities and challenges in global HIV testing efforts.

Type Population Topics Reports Non-US Populations Reports/Presentations Strategizing/ Engagement Methods Testing Conference Proceedings

Preparing for PrEP: A Stakeholders Dialogue (2009) – Report

This report is a summary of a conference proceeding, the goal of the conference was to bring together the best of policy makers, researchers, community advocates, and practitioners to begin a dialogue about the potential of PrEP as a viable strategy in the fight against the global HIV epidemic.

Type Topics Reports Reports/Presentations Pre-Exposure Prophylaxis Conference Proceedings

From Scalpel to Scale-Up: Shaping Perceptions of Male Circumcision (2008) – Report

This report is a summary of a conference proceeding, the goal of this conference was to bring together researchers, community advocacy organizations, policy-makers and donor agencies for a day-long discussion about the communications needed for successful implementation of male circumcision programs.

Type Population Topics Discrimination Reports Non-US Populations Reports/Presentations Stigma Conference Proceedings

The Future Direction of Male Circumcision in HIV Prevention (2007) – Report

This report is a summary of a conference proceeding, the goal of the conference was to identify the opportunities and challenges presented by male circumcisions , and to examine the behavioral, social and policy implications of rolling out circumcisions globally and in the United States.

Type Topics Discrimination Reports Reports/Presentations Stigma Conference Proceedings

HIV Prevention Through Care and Treatment – Program Brief

The Division of HIV and STD Programs (DHSP) at the Los Angeles County (LAC) Department of Public Health is responsible for preventing and controlling HIV and STD infections in LAC. DHSP develops and maintains a comprehensive continuum of HIV prevention, care, and treatment programs for people at risk for or living with HIV or AIDS. This brief summarizes data on the spectrum of engagement in HIV care in LAC, outlines DHSP’s “Testing and Linkage to Care Plus” (TLC+) framework, and describes programs aimed at identifying, engaging, and retaining HIV positive individuals in medical care to achieve viral load suppression and prevent forward transmission of HIV.

Agenda/Flyers Type Antiretroviral Therapy Population Topics Reports Linkage to/ Retention in Care People with HIV (HIV+) Testing Viral Suppression Prevention

HIV Pre-Exposure Prophylaxis Initiative (iPrEx) – Research Brief

The HIV Pre-Exposure Prophylaxis Initiative (iPrEx) was a multinational randomized controlled study of HIV pre-exposure prophylaxis (PrEP) in 2,499 HIV-negative men who have sex with men (MSM) and transgender women who have sex with men. The trial examined the efficacy of Truvada (a fixed dose combination of 2 antiretroviral medications: FTC and Tenofovir) taken every day to prevent HIV infection.

Type Population Topics Reports Men who have sex with men (MSM) PEP/PrEP HIV Infection/ Transmission Publications Transgender Persons Women Pre-Exposure Prophylaxis

Division of HIV/AIDS Prevention Annual Report (2011)

This report provides an overview of HIV prevention activities conducted and supported by the Division of HIV/AIDS Prevention during the Fiscal Year 2011 (October 2010-September 2011). These achievements are made possible by the extraordinary commitment of our partners on the front lines of the HIV epidemic – health departments, community-based organizations (CBOs), people living with HIV, researchers, health care providers, and many more.

Access to Care Type Topics Reports HIV Infection/ Transmission Reports/Presentations Linkage to/ Retention in Care Long-Acting Injectable Pre-Exposure Prophylaxis

LACHNA (Los Angeles County HIV Needs Assessment) Commission Meeting – Report

Los Angeles County Commission Meeting on HIV located at the Foundation Conference Room, St. Anne’s Maternity Home on June 12, 2008. The meeting discussed the prevention planning committee report, State Office of AIDS Report Public Health/Health Care Agency Reports, and Office of AIDS Programs and Policy Report. The meeting listed out committee members including those from the Operations Committee, Joint Public Policy (JPP) Committee, Standards of Care (SOC) Committee, and the Priorities & Planning (P&P) Committee

Type Population Community Health Workers Reports Los Angeles HIV Data Service Providers

Female, Male, and Transgender Sex Workers’ Perspective on HIV & STI Prevention and Treatment Service: A Global Sex Worker Consultation – Report

The WHO is developing guidelines for evidence-based interventions for the prevention and treatment of HIV and other STIs in low- and middle-income countries. As a global partner to the WHO in this process, the Global Network of Sex Work Projects oversaw a civil society consultation of sex workers commissioned by the WHO to gather feedback on proposed guidelines. This report contains the findings from that consultation and was submitted to the WHO.

Type Population Topics Reports HIV Infection/ Transmission Transgender Persons Women Sex Work Sexually Transmitted Infections/ Diseases

Feasibility and Acceptability of PrEP and Non-occupational PEP for HIV Prevention – Final Study Report

This final study report highlighted the results of three focus groups and five key informant interviews that were conducted to assess potential barriers to the acceptance and use of biomedical HIV prevention strategies. A modified grounded-theory approach was used to analyze the interview and focus-group data.

Access to Care Type Topics Los Angeles HIV Data Reports Risk Manuals PEP/PrEP Post-Exposure Prophylaxis Pre-Exposure Prophylaxis

Results of a Pilot Intervention Trial to Improve Antiretroviral Adherence Among HIV-Positive Patients – (PRIDE) Outcome Paper

Results of a small pilot trial of a multicomponent (behavioral strategies, simplified patient information, and social support) and multidisciplinary (cognitive-behavioral therapy and nursing) medication adherence intervention was conducted for HIV-infected adults prescribed antiretrovirals. The intervention, however, did not appear to affect health-related anxiety or to significantly improve adherence to dose. Implications for future intervention planning are discussed.

Adherence Type Antiretroviral Therapy Population Topics Living with HIV Education and Training Risk Reports Manuals Skills Building People with HIV (HIV+) Mental Health