Christina M. Ramirez, PhD

Core Scientist, Methods Core

Christina M. Ramirez, PhD research interests generally relate to uncovering the mechanisms behind HIV and viral pathogenesis. To this end, Christina works closely with investigators in the clinical and basic sciences. Christina is particularly interested in drug resistance mutation/recombination, viral fitness and HIV co-receptor utilization. Christina works to develop methods to understand the evolutionary dynamics of gene regions under the selective pressure of the host immune system and antiretroviral. Christina also is interested in complex, high-dimensional data analysis where we have large p and small n. This has led to the development of machine learning methods for complex data with correlation.

FEATURED PUBLICATIONS:

1. Breen, E. C., Sehl, M. E., Shih, R., Langfelder, P., Wang, R., Horvath, S., Bream, J. H., Duggal, P., Martinson, J., Wolinsky, S. M., Martínez-Maza, O., Ramirez, C. M., & Jamieson, B. D. (2023). Erratum: Accelerated aging with HIV begins at the time of initial HIV infection. iScience, 26(8), 107381. https://doi.org/10.1016/j.isci.2023.107381

2. Gallay, P. A., Ramirez, C. M., & Baum, M. M. (2023). Acute antagonism in three-drug combinations for vaginal HIV prevention in humanized mice. Scientific reports, 13(1), 4594. https://doi.org/10.1038/s41598-023-31695-5

3. Gunawardana, M., Remedios-Chan, M., Sanchez, D., Fanter, R., Webster, S., Webster, P., Moss, J. A., Trinh, M., Beliveau, M., Ramirez, C. M., Marzinke, M. A., Kuo, J., Gallay, P. A., & Baum, M. M. (2023). Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis. Pharmaceutical research, 40(7), 1657–1672. https://doi.org/10.1007/s11095-022-03440-6