Abstract: The UCLA Clinical Research Site (CRS) of the Multicenter AIDS Cohort Study (MACS) / Women’s Interagency HIV Study (WIHS) Combined Cohort Study (CCS) proposes to continue to document clinical, immunologic, physiologic, behavioral, virologic, genetic and psychosocial changes in HIV‐infected and ‐uninfected men‐who‐ have‐sex‐with‐men (MSM). This includes proposed studies to document these changes in MSM recruited previously, as well as plans to recruit new untreated and recently treated HIV‐infected MSM (primarily African‐ and Hispanic‐ Americans), to maintain the cohort. The UCLA CRS will provide leadership and participation in the working groups, CCS‐wide and local studies and research publications, as well as collaborative multi‐ cohort studies, as it has since the inception of the MACS 35 years ago. The UCLA CRS has recruited a large team of early career and established co‐investigators from a wide range of disciplines. These investigators have developed, and are continuing to develop, innovative proposals to advance our understanding of co- morbid conditions that arise in people living with treated HIV infection, as well as the pathophysiology, immunology, genetics and bio-behavioral characteristics of treated and untreated HIV infection. The breadth, enthusiasm, experience and innovation of the UCLA CRS investigators, combined with the experience and commitment of the long‐term staff, and our leadership of several areas of HIV/AIDs research, will continue to play an invaluable role in the success of the CCS over the next seven years.

Project Number: 3U01HL146333-02S1

https://reporter.nih.gov/search/2GhA0lGvQUa0Ika5JZbzxA/project-details/10125498

 

Contact PI/ Project Leader

DETELS, ROGER, PROFESSOR (DETELS@UCLA.EDU)

 

Organization

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

PUBLIC HEALTH RELEVANCE: This is a proposal to continue the UCLA Clinical Research Site (CRS) of the Multicenter AIDS Cohort Study (MACS) / Women’s Interagency HIV Study (WHIS) Combined Cohort Study (CCS), which studies clinical, immunologic, physiologic, behavioral, virologic, genetic and psychosocial changes in HIV‐infected and HIV‐ uninfected men‐who‐have‐sex‐with‐men (MSM). The ongoing studies of the CCS will provide key information to advance our understanding of co-morbid and iatrogenic conditions occurring in people living with HIV infection (PLWH) receiving anti-retroviral therapy (ART), as well as inform the natural history of HIV at the molecular level, psychosocial determinants of disease and treatment compliance, and factors affecting optimal treatment of PLWH.

 

FOA: PA-18-591Study Section: ZHL1(O2)

 

Project Start Date: 15-April-2019

Project End Date: 31-March-2026

Budget Start Date: 01-July-2020

Budget End Date: 31-March-2021

 

NIH Categorical Spending

Funding IC:  NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM/ FY Total Cost by IC:$46,610