A landmark trial in England is to be dramatically sped up after it was found that taking a single dose of the pre-exposure prophylaxis (PrEP) Truvada provided unprecedented levels of protection for those most at risk of infection.
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Analyzing Sexual Behavior from the Healthy Living Project
Robert Weiss, Ph.D.
Department of Biostatistics
UCLA Fielding School of Public Health
Longitudinal behavioral intervention trials to reduce HIV transmission risk collect complex multilevel and multivariate data longitudinally for each subject with important correlation structures across time, level, and variables. Accurately assessing the effects of these trials are critical for determining which interventions are effective. Both numbers of partners and numbers of sex acts with each partner are reported at each time point. Sex acts with each partner are further differentiated into protected and unprotected acts with correspondingly differing risks of HIV/STD transmission. These trials generally also have eligibility criteria limiting enrollment to participants with some minimal level of risky sexual behavior tied directly to the outcome of interest. The combination of these factors makes it difficult to quantify sexual behaviors and the effects of intervention. We propose a multivariate multilevel count model that simultaneously models the number of partners, acts within partners, and accounts for recruitment eligibility. Our methods are useful in the evaluation of intervention trials and provide a more accurate and complete model for sexual behavior. This is joint work with Yuda Zhu.
Robert Weiss is professor in the department of Biostatistics in the UCLA Fielding School of Public Health and a member of the CHIPTS methods core. He is expert in analysis of longitudinal data. He develops statistical methodology for longitudinally collected univariate and multivariate psychometric data, and human behavior generally such as retention in care, self-reported substance use and sexual behaviors. He is author of the advanced introductory textbook Modeling Longitudinal Data (Springer, 2005).
1. Domestic social and behavioral HIV research
The Center for HIV, Identification, Prevention and Treatment Services (CHIPTS) is accepting pilot grant applications for domestic social, behavioral and policy research studies relevant to HIV/AIDS in Los Angeles County, from faculty investigators, postdoctoral fellows, and graduate students at CHIPTS affiliated institutions (i.e., UCLA and Friends Research Institute). A total of $90,000 is available to fund Investigator awards up to $30,000 and postdoctoral and graduate student awards up to $15,000. It is anticipated that three to four proposals will be funded.
The goal of this request for pilot applications is to prepare CHIPTS researchers and its collaborative partners to develop innovative research consistent with or related to the Center priorities of eliminating HIV in Los Angeles County and to seed funding for larger research projects or intervention programs. Applications are invited on any topic of significance and innovation to current HIV identification, prevention or treatment priorities in Los Angeles County, including but not limited to:
• Behavioral economic interventions
• Innovative mobile and web technology-based strategies to enhance the design, implementation and/or dissemination of interventions to reduce the transmission of HIV
• Retention to HIV care among people living with HIV
• Test and treat among disproportionately affected populations in Los Angeles, such as transgender and young African-American and Latino MSM
• Combination prevention approaches that integrate biomedical and behavioral strategies
• HIV-related stigma, including the intersection of perceived and experience stigma, ethnicity and sexual orientation, and interactions with care givers, family, and community
• Social network intervention research
• Treatment adherence and achieving undetectable viral load and decreased community viral load
• Policy and services impacts related to the Affordable Care Act
Domestic social and behavioral HIV research that includes biomarkers or other clinical interventions
CHIPTS is also collaborating with the UCLA Center for AIDS Research (CFAR)/AIDS Institute to support a targeted call. Up to $20,000 is available for a domestic social and behavioral HIV research project that includes biomarkers. Research proposals could include biomarkers such as ARV levels or substance use in hair, nails, taggants, exhalants, or urine.
Application deadline: Wednesday, November 26th, 2014
All applicants should follow the instructions below:
Eligible applicants are limited to research scientists who had or have a working relationship with a community-based organization that can assist in formative research, access to subjects, or data collection. Community-based organizations are only eligible to apply if they have a working relationship with a research scientist from UCLA or one of the affiliated organizations. This eligibility criterion is necessary because of IRB requirements for the pilot studies.
Any team or individual leading a successful application must agree to meet quarterly with funded project teams to modify and tailor their project’s goals and deliverables based on the information needs for the planning of a community level trial.
Investigators are strongly encouraged to form meaningful partnerships with the community to carry out their projects. The applicant must be Principal Investigator at a CHIPTS institution and assume responsibility for IRB approval of any community partnership proposals.
Pilot applications should be 6 pages (single spaced, ½ inch margins, Arial 11 point font), which includes:
• Specific aims (~½ page)
• Research plan (inc. significance, background, preliminary studies).
• A statement of the aspect of the Los Angeles County MSM or MSM/W epidemic that the pilot activity addresses.
• A statement of previous success in conducting pilot research projects, literature reviews, secondary analyses, or collaborative research projects.
• A statement of anticipated goals and work plan.
Applications which do not follow the above guidelines, including those which exceed the page limit, may be returned without review. References may be included on additional page(s).
Click here to download the application packet: CHIPTS 2014 Pilot Call (18)]]>
At 15, while battling depression in the wake of the bullying she faced, Rawl attempted suicide by taking one pill for each year of her life.
Fortunately she survived, and at 19 she is now an advocate and mentor helping to educate kids about the dangers of bullying and spreading awareness of HIV and AIDS.
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Treatment was especially scant among young men and black men, says the report from the federal Centers for Disease Control and Prevention, published Thursday in Morbidity and Mortality Weekly Report.
The report is the latest evidence that “one of the most powerful tools for protecting people’s health and preventing new HIV infections is reaching only a fraction of the gay men who need it,” says David Purcell, deputy director for behavioral and social science in the CDC’s HIV prevention division.
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Other highlights of the event featured Jordan Lake, MD and Danielle Campbell, MPH, who presented on the importance of participation in clinical trials and why research is important. Also, Nina Harawa, PhD, a core investigator on the CHIPTS Policy Core, led an interactive session exploring the relationship between women and their men who have sex with men and women (MSMW) partners. Kara Chew, MD, a physician at the UCLA CARE Center, also presented on the newest treatments for Hepatitis C and on the transmission and effects of the virus itself.
The event was sponsored by the Magic Johnson Foundation. Among the community partners and supporters of the event included Venice Family Clinic/Common Ground, East LA Women’s Center, UCLA Center for Behavioral and Addiction Medicine (CBAM), UCLA Center for HIV Identification, Prevention and Treatment Services (CHIPTS), UCLA CARE Center, Charles Drew University, JWCH Institute, Special Services for Groups/APAIT, and many others.]]>
UCLA CFAR/AIDS Institute Grand Rounds
This monthly lecture series, which is offered by the UCLA CFAR / AIDS Institute, consists of hour-long lunchtime lectures, delivered by invited guests or distinguished members of the Institute faculty, on a broad range of subjects. The aims of the program are to highlight important developments in AIDS-related research, encourage collaborations between UCLA investigators and invited speakers, interest young investigators in AIDS research, and provide information about new findings and new funding opportunities.
The event was sponsored by UCLA Center for HIV Identification, Prevention and Treatment Services (NIMH grant #MH058107) and the Center for Behavioral and Addiction Medicine.
For a copy of the opening presentation, please click here. (24)]]>